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Article

ECM deposition is driven by caveolin-1–dependent regulation of exosomal biogenesis and cargo sorting

4 Aug 2020

Abstract excerpt

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction critically depends on cell communication mediated by exosomes, small vesicles generated within multivesicular bodies (MVBs). We show that caveolin-1 (Cav1) centrally regulates exosome biogenesis and...

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PMID: 33053168
DOI: 10.1083/jcb.202006178

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