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Article

A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity

26 Aug 2015

Abstract excerpt

Loss of the tumour suppressor PTEN is frequent in human melanoma, results in MAPK activation, suppresses senescence and mediates metastatic behaviour. How PTEN loss mediates these effects is unknown. Here we show that loss of PTEN in epithelial and melanocytic cell lines induces the nuclear localization and transcriptional activation of β-catenin independent of the PI3K-AKT-GSK3β axis. The absence of PTEN leads...

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PMID: 26307673
DOI: 10.1038/ncomms9093

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