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Article

Self-assembly and conformational heterogeneity of the AXH domain of ataxin-1: an unusual example of a chameleon fold.

Biophysical journal - 19 Mar 2013

de Chiara Cesira, Rees Martin, Menon Raj P, Pauwels Kris, Lawrence Ceri, Konarev Petr V, Svergun Dmitri I, Martin Stephen R, Chen Yu Wai, Pastore Annalisa

Abstract excerpt

Ataxin-1 is a human protein responsible for spinocerebellar ataxia type 1, a hereditary disease associated with protein aggregation and misfolding. Essential for ataxin-1 aggregation is the anomalous expansion of a polyglutamine tract near the protein N-terminus, but the sequence-wise distant AXH domain modulates and contributes to the process. The AXH domain is also involved in the nonpathologic functions of the...

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Identifiers

PMID: 23528090
DOI: 10.1016/j.bpj.2013.01.048
PMCID: PMC3602761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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