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Article

UGT polymorphisms and lamotrigine clearance during pregnancy.

Epilepsy research - 1 Feb 2018

Petrenaite Vaiva, Öhman Inger, Ekström Lena, Sæbye Ditte, Hansen Thomas Folkmann, Tomson Torbjörn, Sabers Anne

Abstract excerpt

OBJECTIVE: To evaluate the impact of maternal UGT1A4 and UGT2B7 genetic polymorphisms and sex of foetus on gestation-induced changes in lamotrigine (LTG) clearance during pregnancy and post-partum (PP). METHODS: Single nucleotide polymorphisms UGT1A4 142T > G, L48V (*3), UGT1A4 70C > A, P24T (*2) and UGT2B7 802C > T, H268Y (*2) were determined in 40 women (47 pregnancies) with epilepsy treated with LTG....

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Identifiers

PMID: 29395496
DOI: 10.1016/j.eplepsyres.2018.01.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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