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Article

UGT polymorphisms and epileptic seizure control in pregnant women treated with Lamotrigine.

Epilepsy research - 1 Jul 2025

Hansen Nadja Skadkær, Öhman Inger, Ekström Lena, Petrenaite Vaiva

Abstract excerpt

OBJECTIVE: We investigated whether polymorphisms of selected uridine-diphospho-glucuronosyl-tranferases (UGT) involved in Lamotrigine (LTG) metabolism are associated with seizure control during pregnancy and post-partum in women with epilepsy treated with LTG. METHODS: Single nucleotide polymorphisms for UGT1A4 * 2 (P24T, c.70 C>A), UGT1A4 * 3 (L48V c.142 T > G) and UGT2B7 * 2 (H268Y, c.802 C>T), were determined...

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Source

Identifiers

PMID: 40222317
DOI: 10.1016/j.eplepsyres.2025.107554

Genes

UGT1A4
UGT2B7

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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