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Article

Pax6-induced alteration of cell fate: shape changes, expression of neuronal alpha tubulin, postmitotic phenotype, and cell migration.

Journal of neurobiology - 1 Apr 2006

Cartier Laetitia, Laforge Terese, Feki Anis, Arnaudeau Serge, Dubois-Dauphin Michel, Krause Karl-Heinz

Abstract excerpt

The transcription factor Pax6 plays an important role in the development of the central nervous system. To understand its mechanism of action, we transduced HeLa cells with a Pax6-expressing lentiviral vector. Upon transduction, HeLa cells markedly changed shape and formed neuritelike extensions. Pax6-transduced HeLa cells expressed high levels of neuronal alpha3 tubulin, demonstrating a partial...

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Identifiers

PMID: 16425216
DOI: 10.1002/neu.20225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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