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Article

Synthesis and hydrolysis of pppGpp in mycobacteria: a ligand mediated conformational switch in Rel.

Biophysical chemistry - 1 Apr 2007

Jain Vikas, Saleem-Batcha Raspudin, Chatterji Dipankar

Abstract excerpt

Bacteria respond to starvation by synthesizing a polyphosphate derivative of guanosine, (p)ppGpp, that helps the bacteria in surviving during stress. The protein in Gram-positive organisms required for (p)ppGpp synthesis is Rel, a bifunctional enzyme that carries out both synthesis and hydrolysis of this molecule. Rel shows increased pppGpp synthesis in the presence of uncharged tRNA, the effect of which is...

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Identifiers

PMID: 17188418
DOI: 10.1016/j.bpc.2006.12.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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