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Role of RelA of Streptococcus mutans in Global Control of Gene Expression

19 Oct 2007

Abstract excerpt

The production of (p)ppGpp by Streptococcus mutans UA159 is catalyzed by three gene products: RelA, RelP, and RelQ. Here, we investigate the role of the RelA (Rel) homologue of S. mutans in the stringent response and in the global control of gene expression. RelA of S. mutans was shown to synthesize pppGpp in vitro from GTP and ATP in the absence of added ribosomes, as well as in vivo in an Escherichia coli...

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PMID: 17951382
DOI: 10.1128/jb.01395-07

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