Article
Papillary thyroid carcinoma tall cell variant shares accumulation of mitochondria, mitochondrial DNA mutations, and loss of oxidative phosphorylation complex I integrity with oncocytic tumors.
The journal of pathology. Clinical research - 1 Mar 2022
Tsybrovskyy Oleksiy, De Luise Monica, de Biase Dario, Caporali Leonardo, Fiorini Claudio, Gasparre Giuseppe, Carelli Valerio, Hackl Dominik, Imamovic Larisa, Haim Silke, Sobrinho-Simões Manuel, Tallini Giovanni
Abstract excerpt
Papillary thyroid carcinoma tall cell variant (PTC-TCV), a form of PTC regarded as an aggressive subtype, shares several morphologic features with oncocytic tumors. Pathogenic homoplasmic/highly heteroplasmic somatic mitochondrial DNA (mtDNA) mutations, usually affecting oxidative phosphorylation (OXPHOS) complex I subunits, are hallmarks of oncocytic cells. To clarify the relationship between PTC-TCV and...
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