Article
Rare Variants in Tissue Inhibitor of Metalloproteinase 2 as a Risk Factor for Schizophrenia: Evidence From Familial and Cohort Analysis.
Schizophrenia bulletin - 1 Jan 2019
John Jibin, Sharma Aditya, Kukshal Prachi, Bhatia Triptish, Nimgaonkar Vishwajit L, Deshpande Smita N, Thelma B K
Abstract excerpt
Candidate gene and genome-wide association study based common risk variant identification is being complemented by whole exome sequencing (WES)/whole genome sequencing based rare variant discovery in elucidation of genetic landscape of schizophrenia (SZ), a common neuropsychiatric disorder. WES findings of de novo mutations in case-parent trios have further implied genetic etiology, but do not explain the high...
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