Residue conservation and solvent accessibility are (almost) all you need for predicting mutational effects in proteins.

Abstract excerpt

MOTIVATION: Predicting how mutations impact protein biophysical properties remains a significant challenge in computational biology. In recent years, numerous predictors, primarily deep learning models, have been developed to address this problem; however, issues such as their lack of interpretability and limited accuracy persist. RESULTS: We showed that a simple evolutionary score, based on the log-odd ratio of...

Topics

• Proteins
• Mutation
• Solvents
• Computational Biology
• Software
• Databases, Protein
• Evolution, Molecular