Article
Genetic variation of the gene coding for microRNA-204 (miR-204) is a risk factor in acute myeloid leukaemia.
BMC cancer - 30 Jan 2018
Butrym Aleksandra, Łacina Piotr, Kuliczkowski Kazimierz, Bogunia-Kubik Katarzyna, Mazur Grzegorz
Abstract excerpt
BACKGROUND: MicroRNAs (miRNAs or miRs) are small molecules known to be involved in post-transcriptional gene expression. Many of them have been shown to influence risk for various diseases. Recent studies suggest that lower expression of miR-204, a gene coding for miRNA-204, is correlated with shorter survival in patients with acute myeloid leukaemia (AML). This observation prompted us to analyse the effect of...
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