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Gene Variants in Components of the microRNA Processing Pathway in Chronic Myeloid Leukemia.

Genes - 10 Aug 2024

Chavaro-Francisco Guillermina, Hernández-Zavala Araceli, Bravo-Cidro Camila E, Rios-Rodriguez Sandybel, Muciño-Sánchez Mabel, López-López Marisol, Castro-Martínez Xóchitl H, Olarte-Carrillo Irma, Garcia-Laguna Anel, Barranco-Lampón Gilberto, De la Cruz-Rosas Adrián, Martínez-Tovar Adolfo, Córdova Emilio J

Abstract excerpt

Current therapy in chronic myeloid leukemia (CML) has improved patient life expectancy close to that of healthy individuals. However, molecular alterations other than BCR::ABL1 fusion gene in CML are barely known. MicroRNAs are important regulators of gene expression, and variants in some of the components of microRNA biosynthesis pathways have been associated with genetic susceptibility to different types of...

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Identifiers

PMID: 39202414
DOI: 10.3390/genes15081054
PMCID: PMC11353722

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