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Article

Altered HIV-1 mRNA Splicing Due to Drug-Resistance-Associated Mutations in Exon 2/2b.

International journal of molecular sciences - 23 Dec 2021

Müller Lisa, Moskorz Wiebke, Brillen Anna-Lena, Hillebrand Frank, Ostermann Philipp Niklas, Kiel Niklas, Walotka Lara, Ptok Johannes, Timm Jörg, Lübke Nadine, Schaal Heiner

Abstract excerpt

The underlying molecular mechanism and their general effect on the replication capacity of HIV 1 drug-resistance-associated mutations is often poorly understood. To elucidate the effect of two such mutations located in a region with a high density of spicing regulatory elements on the HIV-1-splicing outcome, bioinformatic predictions were combined with transfection and infection experiments. Results show that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35008581
DOI: 10.3390/ijms23010156
PMCID: PMC8745674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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