Article
The Silent Sway of Splicing by Synonymous Substitutions.
The Journal of biological chemistry - 13 Nov 2015
Mueller William F, Larsen Liza S Z, Garibaldi Angela, Hatfield G Wesley, Hertel Klemens J
Abstract excerpt
Alternative splicing diversifies mRNA transcripts in human cells. This sequence-driven process can be influenced greatly by mutations, even those that do not change the protein coding potential of the transcript. Synonymous mutations have been shown to alter gene expression through modulation of splicing, mRNA stability, and translation. Using a synonymous position mutation library in SMN1 exon 7, we show that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.