Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Establishment of a CRISPR/Cas9-Mediated Cysltr1 Knockout Mouse Model and iTRAQ-Based Proteomic Analysis.

Proteomics. Clinical applications - 1 May 2018

Mao Junjie, Hu Xiaojun, Pang Pengfei, Zhou Bin, Zhang Yaqin, Li Dan, Shan Hong

Abstract excerpt

PURPOSE: To clarify the role of Cysteinyl leukotrienes receptor type 1 (CYSLTR1) and find the potential predictors of CYSLTR1 antagonists (leukotriene receptor antagonists [LTRAs]) responsiveness in vivo. EXPERIMENTAL DESIGN: Cysltr1 knockout (KO) mouse model is established by the CRISPR/Cas9 system. The phenotype of Cysltr1 KO mice are tested by western blotting (WB), histological examinations, and experiment of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR-Cas Systems
Share to Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Nitric Oxide

Share to Phenotype

Share to Proteomics

Source

Identifiers

PMID: 29377627
DOI: 10.1002/prca.201700087

Genes

CYSLTR1
DDAH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Establishment of a CRISPR/Cas9-Mediated Cysltr1 Knockout Mouse Model and iTRAQ-Based Proteomic Analysis.PMID 29377627Read ↗

Generation and phenotype analysis of CysLTR1 L118F mutant mice.Semantic proximity Read ↗

Functional Characterization of Human Cysteinyl Leukotriene 1 Receptor Gene StructureSemantic proximity Read ↗

Cysteinyl‐leukotrienes and their receptors in asthma and other inflammatory diseases: Critical update and emerging trendsSemantic proximity Read ↗

Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammationSemantic proximity Read ↗

Genome editing of PAR2 through targeted delivery of CRISPR-Cas9 system for alleviating acute lung inflammation via ERK/NLRP3/IL-1β and NO/iNOS signallingSemantic proximity Read ↗

Expression and Genetic Loss of Function Analysis of the HAT/DESC Cluster Proteases TMPRSS11A and HATSemantic proximity Read ↗

Chemerin in immunitySemantic proximity Read ↗

Gene targeting technology and advances in the pathophysiology of inflammation.Semantic proximity Read ↗

MicroRNA regulation postbleomycin due to the R213G extracellular superoxide dismutase variant is predicted to suppress inflammatory and immune pathways.Semantic proximity Read ↗

Cysteinyl leukotrienes in allergic inflammation: strategic target for therapy.Semantic proximity Read ↗

Shank2 mutant mice display a hypersecretory response to cholera toxin.Semantic proximity Read ↗

Behavioral characterization of a CRISPR-generated TRPA1 knockout rat in models of pain, itch, and asthma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.