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Article

Generation and phenotype analysis of CysLTR1 L118F mutant mice.

Journal of cellular biochemistry - 1 Mar 2020

Hu Xiaojun, Mao Junjie, Zhou Bin, Zhang Huitao, Li Bing, Pang Pengfei, Shan Hong

Abstract excerpt

Cysteinyl leukotrienes (CysLTs) are a group of eicosanoids that regulate the pathogenesis of various human diseases, mainly by signaling through the cysteinyl leukotriene receptor 1 (CysLTR1). The aim of this study was to generate and examine the phenotype of CysLTR1 L118F mutant mice. CysLTR1 L118F mutant mice were generated by the simultaneous microinjection of single guide RNA, Cas9 messenger RNA, and donor...

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Identifiers

PMID: 31742746
DOI: 10.1002/jcb.29460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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