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Article

Shank2 mutant mice display a hypersecretory response to cholera toxin.

The Journal of physiology - 15 Apr 2014

Jung Eun Suk, Park Joonhee, Gee Heon Yung, Jung Jinsei, Noh Shin Hye, Lee Jung-Soo, Richter Wito, Namkung Wan, Lee Min Goo

Abstract excerpt

Shank2 is a PDZ (PSD-95/discs large/ZO-1)-based adaptor that has been suggested to regulate membrane transporting proteins in the brain and epithelial tissues. Here, we report that Shank2 mutant (Shank2(-/-)) mice exhibit aberrant fluid and ion transport in the intestine. Molecular characterization using epithelial tissues from Shank2(+/+) and Shank2(-/-) mice revealed that a long spliceoform of Shank2 (Shank2E)...

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Share to Chlorides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic Nucleotide Phosphodiesterases, Type 4

Share to Cystic Fibrosis Transmembrane Conductance Regulator

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Source

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Identifiers

PMID: 24445315
DOI: 10.1113/jphysiol.2013.268631
PMCID: PMC4001754

Genes

CFTR
PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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