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Tricyclic nitrogen base 1,N6-ethenoadenine and its ribosides as substrates for purine-nucleoside phosphorylases: Spectroscopic and kinetic studies.

Nucleosides, nucleotides & nucleic acids - 1 Feb 2018

Stachelska-Wierzchowska Alicja, Wierzchowski Jacek, Bzowska Agnieszka, Wielgus-Kutrowska Beata

Abstract excerpt

The title compound is an excellent substrate for E. coli PNP, as well as for its D204N mutant. The main product of the synthetic reaction is N9-riboside, but some amount of N7-riboside is also present. Surprisingly, 1,N6-ethenoadenine is also ribosylated by both wild-type and mutated (N243D) forms of calf PNP, which catalyze the synthesis of a different riboside, tentatively identified as...

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PMID: 29376769
DOI: 10.1080/15257770.2017.1419255

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PNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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