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Article

Physiological and toxic effects of purine intermediate 5-amino-4-imidazolecarboxamide ribonucleotide (AICAR) in yeast.

The Journal of biological chemistry - 2 Sept 2011

Hürlimann Hans C, Laloo Benoît, Simon-Kayser Barbara, Saint-Marc Christelle, Coulpier Fanny, Lemoine Sophie, Daignan-Fornier Bertrand, Pinson Benoît

Abstract excerpt

5-Amino-4-imidazolecarboxamide ribonucleotide 5'-phosphate (AICAR) is a monophosphate metabolic intermediate of the de novo purine synthesis pathway that has highly promising metabolic and antiproliferative properties. Yeast mutants unable to metabolize AICAR are auxotroph for histidine. A screening for suppressors of this phenotype identified recessive and dominant mutants that result in lowering the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21757731
DOI: 10.1074/jbc.M111.262659
PMCID: PMC3162458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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