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Article

CRISPR/Cas9-mediated modification of the extreme C-terminus impairs PDGF-stimulated activity of Duox2.

Biological chemistry - 25 Apr 2018

Tyurin-Kuzmin Pyotr A, Karagyaur Maxim N, Rubtsov Yury P, Dyikanov Daniyar T, Vasiliev Pyotr A, Vorotnikov Alexander V

Abstract excerpt

Duox2 belongs to the large family of NADPH-oxidase enzymes that are implicated in immune response, vasoregulation, hormone synthesis, cell growth and differentiation via the regulated synthesis of H2O2 and reactive oxygen species. We and others have shown that Duox2 and H2O2 are involved in platelet-derived growth factor (PDGF) induced migration of fibroblasts. Now, using the CRISPR/Cas9-mediated genome editing...

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Identifiers

PMID: 29373314
DOI: 10.1515/hsz-2017-0229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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