Article
Nanoparticle-Mediated Trapping of Wnt Family Member 5A in Tumor Microenvironments Enhances Immunotherapy for B-Raf Proto-Oncogene Mutant Melanoma.
ACS nano - 27 Feb 2018
Liu Qi, Zhu Hongda, Tiruthani Karthik, Shen Limei, Chen Fengqian, Gao Keliang, Zhang Xueqiong, Hou Lin, Wang Degeng, Liu Rihe, Huang Leaf
Abstract excerpt
Development of an effective treatment against advanced tumors remains a major challenge for cancer immunotherapy. Approximately 50% of human melanoma is driven by B-Raf proto-oncogene mutation (BRAF mutant). Tumors with such mutation are desmoplastic, highly immunosuppressive, and often resistant to immune checkpoint therapies. We have shown that immunotherapy mediated by low-dose doxorubicin-induced immunogenic...
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