Article
In Vitro Biophysical and Biological Characterization of Lipid Nanoparticles Co-Encapsulating Oncosuppressors miR-199b-5p and miR-204-5p as Potentiators of Target Therapy in Metastatic Melanoma.
International journal of molecular sciences - 12 Mar 2020
Fattore Luigi, Campani Virginia, Ruggiero Ciro Francesco, Salvati Valentina, Liguoro Domenico, Scotti Lorena, Botti Gerardo, Ascierto Paolo Antonio, Mancini Rita, De Rosa Giuseppe, Ciliberto Gennaro
Abstract excerpt
Uncontrolled MAPK signaling is the main oncogenic driver in metastatic melanomas bearing mutations in BRAF kinase. These tumors are currently treated with the combination of BRAF/MEK inhibitors (MAPKi), but this therapy is plagued by drug resistance. In this context we recently discovered that several microRNAs are involved in the development of drug resistance. In particular miR-204-5p and miR-199b-5p were found...
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