Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of MGMT polymorphisms rs12917 and rs11016879 in head and neck cancer risk and prognosis.

Acta biochimica Polonica - 1 Jan 2018

Kiczmer Paweł, Prawdzic Seńkowska Alicja, Strzelczyk Joanna Katarzyna, Szydło Błażej, Biernacki Krzysztof, Osadnik Tadeusz, Krakowczyk Łukasz, Ostrowska Zofia

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) is one of the leading cancers by incidence worldwide. The risk of these cancers is strictly associated with alkylation factors present in tobacco smoke. The crucial role in preventing DNA alkylation is played by O6-methylguanine-DNA methyltransferase (MGMT). Dysfunction or lack of MGMT is associated with an increased risk of cancer. The aim of the study was to assess...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to DNA Modification Methylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair Enzymes

Share to Head and Neck Neoplasms

Share to Homozygote

Share to Neoplasm Metastasis

Share to Squamous Cell Carcinoma of Head and Neck

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 29370316
DOI: 10.18388/abp.2017_1613

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of MGMT polymorphisms rs12917 and rs11016879 in head and neck cancer risk and prognosis.PMID 29370316Read ↗

Polymorphisms of the DNA repair gene MGMT and risk and progression of head and neck cancer.Semantic proximity Read ↗

Analysis of Association Between MGMT and p53 Gene Single Nucleotide Polymorphisms and Laryngeal Cancer.Semantic proximity Read ↗

O6-methylguanine-DNA methyltransferase gene coding region polymorphisms and oral cancer risk.Semantic proximity Read ↗

Association between genetic polymorphisms in DNA mismatch repair-related genes with risk and prognosis of head and neck squamous cell carcinoma.Semantic proximity Read ↗

The A/G allele of rs16906252 predicts for MGMT methylation and is selectively silenced in premalignant lesions from smokers and in lung adenocarcinomas.Semantic proximity Read ↗

DNMT3B C46359T and SHMT1 C1420T polymorphisms in the folate pathway in carcinogenesis of head and neck.Semantic proximity Read ↗

Involvement of single-nucleotide polymorphisms in predisposition to head and neck cancer in Saudi Arabia.Semantic proximity Read ↗

Association of DNA repair genes polymorphisms and mutations with increased risk of head and neck cancer: a review.Semantic proximity Read ↗

Effects of tobacco on the DNA of smokers and non-smokers affected by OSCC: systematic review and meta-analysis.Semantic proximity Read ↗

<i>O</i> 6 <i>-Methylguanine-DNA Methyltransferase</i> Gene: Epigenetic Silencing and Prognostic Value in Head and Neck Squamous Cell CarcinomaSemantic proximity Read ↗

Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: a case-control study.Semantic proximity Read ↗

Promoter methylation and polymorphisms of the MGMT gene in glioblastomas: a population-based study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.