Association between genetic polymorphisms in DNA mismatch repair-related genes with risk and prognosis of head and neck squamous cell carcinoma.

doi:10.1002/ijc.29435

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Article

Association between genetic polymorphisms in DNA mismatch repair-related genes with risk and prognosis of head and neck squamous cell carcinoma.

International journal of cancer - 15 Aug 2015

Nogueira Guilherme Augusto Silva, Lourenço Gustavo Jacob, Oliveira Camila Borges Martins, Marson Fernando Augusto Lima, Lopes-Aguiar Leisa, Costa Ericka Francislaine Dias, Lima Tathiane Regine Penna, Liutti Vitor Teixeira, Leal Frederico, Santos Vivian Castro Antunes, Rinck-Junior José Augusto, Lima Carmen Silvia Passos

Abstract excerpt

We examined the influence of MLH1 c.-93G>A, MSH2 c.211 + 9C>G, MSH3 c.3133G>A and EXO1 c.1765G>A polymorphisms, involved in DNA mismatch repair (MMR), on head and neck (HN) squamous cell carcinoma (SCC) risk and prognosis. Aiming to identify genotypes, DNA from 450 HNSCC patients and 450 controls was analyzed by PCR-RFLP or real time PCR. MSH2 GG plus MSH3 GG (31.7% vs. 18.7%, p = 0.003) genotypes were higher in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25598504
DOI: 10.1002/ijc.29435

Genes

MSH3
EXO1
MSH2
MLH1

Variants

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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