Article
O6-methylguanine-DNA methyltransferase gene coding region polymorphisms and oral cancer risk.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Sept 2010
Huang Sung-Hsien, Chang Pei-Yang, Liu Chung-Ji, Lin Ming-Wei, Hsia Kan-Tai
Abstract excerpt
BACKGROUND: O (6) -methylguanine-DNA methyltransferase (MGMT) is a specific DNA direct reversal repair protein which ameliorates mutagenic, carcinogenic and cytotoxic adducts from O(6) -methylguanine in DNA. The aim of this study was to investigate the potential association between six polymorphisms in the coding region of the MGMT gene and oral cancer risk in Taiwanese population. METHODS: In this hospital-based...
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