Article
[The heteroplasmy level of some mutations in gene MT-CYB among women with asymptomatic atherosclerosis].
Genetika - 1 Aug 2016
Sinyov V V, Chicheva M M, Barinova V A, Ryzhkova A I, Zilinyi R I, Karagodin V P, Postnov A Yu, Sobenin I A, Orekhov A N, Sazonova M A
Abstract excerpt
Atherosclerosis is a polygenic socially significant disease whose risk factors include coronary heart disease, diabetes, hypertension, and myocardial infarction. According to the literature, mutations m.14846G>A (G34S), m.15762G>A (G339Q), m.15084G>A (W113Ter), and m.15059G>A (G190Ter) of cytochrome B gene (MT-CYB) are associated with mitochondrial myopathies, myoglobinuria, and exercise intolerance. Preliminary...
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