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Article

Farnesoid X receptor antagonist exacerbates dyslipidemia in mice.

Pharmacological reports : PR - 1 Feb 2018

Amano Yuichiro, Yamakawa Hiroko, Yonemori Kazuko, Shimada Mitsuyuki, Tozawa Ryuichi

Abstract excerpt

BACKGROUND: The effects of farnesoid X receptor (FXR) antagonists on plasma lipid profile in mice have not been investigated thus far. The aim of this study was to investigate the antidyslipidemic effects of an FXR antagonist in dyslipidemic mice, and to clarify the mechanisms underlying the lipid modulatory effect. METHODS: Compound-T0 (1-100 mg/kg) was orally administered to C57BL/6J mice fed a Western-type...

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PMID: 29367104
DOI: 10.1016/j.pharep.2017.07.010

Genes

LDLR

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