Article
Low-Density Lipoprotein Receptor-Dependent and Low-Density Lipoprotein Receptor-Independent Mechanisms of Cyclosporin A-Induced Dyslipidemia.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2016
Kockx Maaike, Glaros Elias, Leung Betty, Ng Theodore W, Berbée Jimmy F P, Deswaerte Virginie, Nawara Diana, Quinn Carmel, Rye Kerry-Anne, Jessup Wendy, Rensen Patrick C N, Meikle Peter J, Kritharides Leonard
Abstract excerpt
OBJECTIVE: Cyclosporin A (CsA) is an immunosuppressant commonly used to prevent organ rejection but is associated with hyperlipidemia and an increased risk of cardiovascular disease. Although studies suggest that CsA-induced hyperlipidemia is mediated by inhibition of low-density lipoprotein receptor (LDLr)-mediated lipoprotein clearance, the data supporting this are inconclusive. We therefore sought to...
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