Article
Evolutionary conservation of drug action on lipoprotein metabolism-related targets.
Journal of lipid research - 1 Jan 2008
Hihi Abdelmadjid K, Beauchamp Marie-Claude, Branicky Robyn, Desjardins Annick, Casanova Isabel, Guimond Marie-Pierre, Carroll Melissa, Ethier Melanie, Kianicka Irenej, McBride Kevin, Hekimi Siegfried
Abstract excerpt
Genetic analysis has shown that the slower than normal rhythmic defecation behavior of the clk-1 mutants of Caenorhabditis elegans is the result of altered lipoprotein metabolism. We show here that this phenotype can be suppressed by drugs that affect lipoprotein metabolism, including drugs that affect HMG-CoA reductase activity, reverse cholesterol transport, or HDL levels. These pharmacological effects are...
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