Article
Isolation of a putative Candida albicans transcriptional regulator involved in pleiotropic drug resistance by functional complementation of a pdr1 pdr3 mutation in Saccharomyces cerevisiae.
Journal of bacteriology - 1 Jan 1999
Talibi D, Raymond M
Abstract excerpt
Three Candida albicans genes, designated FCR (for fluconazole resistance), have been isolated by their ability to complement the fluconazole (FCZ) hypersensitivity of a Saccharomyces cerevisiae mutant lacking the transcription factors Pdr1p and Pdr3p. Overexpression of any of the three FCR genes...
Topics
- Amino Acid Sequence
- Antifungal Agents
- Base Sequence
- Candida albicans
- Cloning, Molecular
- DNA Primers
- DNA, Fungal
- DNA-Binding Proteins
- Drug Resistance, Microbial
- Fluconazole
- Fungal Proteins
- Genes, Fungal
- Genetic Complementation Test
- Molecular Sequence Data
- Mutation