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Article

Molecular interactions of type I and type II positive allosteric modulators with the human α7 nicotinic acetylcholine receptor: an in silico study.

Journal of biomolecular structure & dynamics - 1 Feb 2019

Targowska-Duda Katarzyna M, Kaczor Agnieszka A, Jozwiak Krzysztof, Arias Hugo R

Abstract excerpt

The binding site locations and structural components for type I and type II positive allosteric modulators (PAMs) of the α7 nicotinic acetylcholine receptor (nAChR) have not been fully characterized yet. In this regard, homology models of the human α7 nAChR and hα7/m5-HT3A chimera, built using the crystal structure of the serotonin type 3A receptor (5-ΗΤ3ΑR), were used for molecular docking and molecular dynamics...

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Source

Identifiers

PMID: 29363414
DOI: 10.1080/07391102.2018.1427634

Genes

ECD
PAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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