Article
BCG vaccination drives accumulation and effector function of innate lymphoid cells in murine lungs.
Immunology and cell biology - 1 Apr 2018
Steigler Pia, Daniels Naomi J, McCulloch Tim R, Ryder Brin M, Sandford Sarah K, Kirman Joanna R
Abstract excerpt
The tuberculosis (TB) vaccine bacille Calmette-Guérin (BCG) prevents disseminated childhood TB; however, it fails to protect against the more prevalent pulmonary TB. Limited understanding of the immune response to Mycobacterium tuberculosis, the causative agent of TB, has hindered development of improved vaccines. Although memory CD4 T cells are considered the main mediators of protection against TB, recent...
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