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Article

Role of Complex Epigenetic Switching in Tumor Necrosis Factor-α Upregulation in the Prefrontal Cortex of Suicide Subjects.

The American journal of psychiatry - 1 Mar 2018

Wang Qingzhong, Roy Bhaskar, Turecki Gustavo, Shelton Richard C, Dwivedi Yogesh

Abstract excerpt

OBJECTIVE: Proinflammatory cytokines have recently received considerable attention for their role in suicidal behavior; however, how the expression of cytokine genes is regulated is not clearly known. The authors examined underlying mechanisms of critical cytokine gene tumor necrosis factor-alpha (TNF-α) dysregulation in the brains of individuals who died by suicide. METHOD: TNF-α expression was examined in the...

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Identifiers

PMID: 29361849
DOI: 10.1176/appi.ajp.2017.16070759
PMCID: PMC5832541

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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