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Article

Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells.

Brain : a journal of neurology - 1 Mar 2018

Smets Ide, Fiddes Barnaby, Garcia-Perez Josselyn E, He Di, Mallants Klara, Liao Wenjia, Dooley James, Wang George, Humblet-Baron Stephanie, Dubois Bénédicte, Compston Alastair, Jones Joanne, Coles Alasdair, Liston Adrian, Ban Maria, Goris An, Sawcer Stephen

Abstract excerpt

The increasing evidence supporting a role for B cells in the pathogenesis of multiple sclerosis prompted us to investigate the influence of known susceptibility variants on the surface expression of co-stimulatory molecules in these cells. Using flow cytometry we measured surface expression of CD40 and CD86 in B cells from 68 patients and 162 healthy controls that were genotyped for the multiple sclerosis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29361022
DOI: 10.1093/brain/awx372
PMCID: PMC5837558

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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