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Article

A multiple sclerosis-associated variant of CBLB links genetic risk with type I IFN function.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2014

Stürner Klarissa Hanja, Borgmeyer Uwe, Schulze Christian, Pless Ole, Martin Roland

Abstract excerpt

Multiple sclerosis (MS) is an autoimmune disease of the CNS, and autoreactive CD4(+) T cells are considered important for its pathogenesis. The etiology of MS involves a complex genetic trait and environmental triggers that include viral infections, particularly the EBV. Among the risk alleles that have repeatedly been identified by genome-wide association studies, three are located near the Casitas B-lineage...

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Share to Adaptor Proteins, Signal Transducing
Share to CCAAT-Enhancer-Binding Protein-beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4-Positive T-Lymphocytes

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Source

Identifiers

PMID: 25261476
DOI: 10.4049/jimmunol.1303077

Genes

CBLB
CBL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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