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Article

PDCD1 and CTLA4 polymorphisms affect the susceptibility to, and clinical features of, chronic immune thrombocytopenia.

British journal of haematology - 1 Mar 2018

Kasamatsu Tetsuhiro, Ino Rumi, Takahashi Noriyuki, Gotoh Nanami, Minato Yusuke, Takizawa Makiko, Yokohama Akihiko, Handa Hiroshi, Saitoh Takayuki, Tsukamoto Norifumi, Murakami Hirokazu

Abstract excerpt

Programmed death-1 (PD-1, PDCD1) and cytotoxic T lymphocyte-associated antigen-4 (CTLA-4, CTLA4) play central roles in immune checkpoint pathways. Single nucleotide polymorphisms (SNPs) of PDCD1 and CTLA4 have been reported to be associated with susceptibility to some autoimmune diseases. However, the potential association between SNPs in these immune checkpoint genes and risk of chronic immune thrombocytopenia...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CTLA-4 Antigen

Share to Glucocorticoids

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Share to Purpura, Thrombocytopenic, Idiopathic

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Source

Identifiers

PMID: 29359792
DOI: 10.1111/bjh.15085

Genes

PDCD1
CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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