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Article

IFN-γ and TNF-α Pre-licensing Protects Mesenchymal Stromal Cells from the Pro-inflammatory Effects of Palmitate.

Molecular therapy : the journal of the American Society of Gene Therapy - 7 Mar 2018

Boland Lauren, Burand Anthony J, Brown Alex J, Boyt Devlin, Lira Vitor A, Ankrum James A

Abstract excerpt

The use of mesenchymal stromal cell (MSC) therapy for the treatment of type 2 diabetes (T2D) and T2D complications is promising; however, the investigation of MSC function in the setting of T2D has not been thoroughly explored. In our current study, we investigated the phenotype and function of MSCs in a simulated in vitro T2D environment. We show that palmitate, but not glucose, exposure impairs MSC metabolic...

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Identifiers

PMID: 29352647
DOI: 10.1016/j.ymthe.2017.12.013
PMCID: PMC5910660

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MSC
TNF

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