Article
Human Adipose Tissue-Derived Mesenchymal Stem Cells in Parkinson's Disease: Inhibition of T Helper 17 Cell Differentiation and Regulation of Immune Balance Towards a Regulatory T Cell Phenotype.
Clinical interventions in aging - 1 Jan 2020
Bi Yong, Lin Xiaobin, Liang Huazheng, Yang Dehao, Zhang Xiaowei, Ke Jianming, Xiao Jingjing, Chen Zhilin, Chen Weian, Zhang Xu, Wang Shaoshi, Liu Chun-Feng
Abstract excerpt
BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disorder displaying a typical neuroinflammation pathology that may result from an imbalance between regulatory T cells (Treg) and T helper 17 (Th17) cells. Human adipose tissue-derived mesenchymal stem cells (Ad-MSCs) exert immunomodulatory effects by inhibiting effector T cell responses and have been used to treat diverse immune disorders. We aimed to...
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