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Article

Compositional Bias in Naïve and Chemically-modified Phage-Displayed Libraries uncovered by Paired-end Deep Sequencing.

Scientific reports - 19 Jan 2018

He Bifang, Tjhung Katrina F, Bennett Nicholas J, Chou Ying, Rau Andrea, Huang Jian, Derda Ratmir

Abstract excerpt

Understanding the composition of a genetically-encoded (GE) library is instrumental to the success of ligand discovery. In this manuscript, we investigate the bias in GE-libraries of linear, macrocyclic and chemically post-translationally modified (cPTM) tetrapeptides displayed on the M13KE platform, which are produced via trinucleotide cassette synthesis (19 codons) and NNK-randomized codon. Differential...

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Identifiers

PMID: 29352178
DOI: 10.1038/s41598-018-19439-2
PMCID: PMC5775325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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