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Article

Prospective identification of parasitic sequences in phage display screens

9 Nov 2013

Abstract excerpt

Phage display empowered the development of proteins with new function and ligands for clinically relevant targets. In this report, we use next-generation sequencing to analyze phage-displayed libraries and uncover a strong bias induced by amplification preferences of phage in bacteria. This bias favors fast-growing sequences that collectively constitute <0.01% of the available diversity. Specifically, a library...

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PMID: 24217917
DOI: 10.1093/nar/gkt1104

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