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Article

Liver tissue metabolically transformed by alcohol induces immune recognition of liver self-proteins but not in vivo inflammation.

American journal of physiology. Gastrointestinal and liver physiology - 1 Mar 2018

Duryee Michael J, Wiese Benjamin M, Bowman Jordan R, Vanlandingham Jared D, Klassen Lynell W, Thiele Geoffrey E, Hunter Carlos D, Anderson Daniel R, Mikuls Ted R, Thiele Geoffrey M

Abstract excerpt

Precision-cut liver slices (PCLSs) provide a novel model for studies of alcoholic liver disease (ALD). This is relevant, as in vivo ethanol exposure does not appear to generate significant liver damage in ethanol-fed mice, except in the National Institute on Alcohol Abuse and Alcoholism binge model of ALD. Previous studies have shown that the two metabolites of ethanol consumption, malondialdhyde (MDA) and...

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Identifiers

PMID: 29351393
DOI: 10.1152/ajpgi.00183.2017
PMCID: PMC5899239

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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