Article
Ethanol metabolism alters major histocompatibility complex class I-restricted antigen presentation in liver cells.
Hepatology (Baltimore, Md.) - 1 Apr 2009
Osna Natalia A, White Ronda L, Thiele Geoffrey M, Donohue Terrence M
Abstract excerpt
UNLABELLED: The proteasome is a major enzyme that cleaves proteins for antigen presentation. Cleaved peptides traffic to the cell surface, where they are presented in the context of major histocompatibility complex (MHC) class I. Recognition of these complexes by cytotoxic T lymphocytes is crucial for elimination of cells bearing "nonself" proteins. Our previous studies revealed that ethanol suppresses proteasome...
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