Article
Expansion of CD133+ colon cancer cultures retaining stem cell properties to enable cancer stem cell target discovery
23 Mar 2010
Abstract excerpt
BACKGROUND: Despite earlier studies demonstrating in vitro propagation of solid tumour cancer stem cells (CSCs) as non-adherent tumour spheres, it remains controversial as to whether CSCs can be maintained in vitro. Additional validation of the CSC properties of tumour spheres would support their use as CSC models and provide an opportunity to discover additional CSC cell surface markers to aid in CSC detection...