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Article

Phenotypic differentiation does not affect tumorigenicity of primary human colon cancer initiating cells.

Cancer letters - 28 Feb 2016

Dubash Taronish D, Hoffmann Christopher M, Oppel Felix, Giessler Klara M, Weber Sarah, Dieter Sebastian M, Hüllein Jennifer, Zenz Thorsten, Herbst Friederike, Scholl Claudia, Weichert Wilko, Werft Wiebke, Benner Axel, Schmidt Manfred, Schneider Martin, Glimm Hanno, Ball Claudia R

Abstract excerpt

Within primary colorectal cancer (CRC) a subfraction of all tumor-initiating cells (TIC) drives long-term progression in serial xenotransplantation. It has been postulated that efficient maintenance of TIC activity in vitro requires serum-free spheroid culture conditions that support a stem-like state of CRC cells. To address whether tumorigenicity is indeed tightly linked to such a stem-like state in spheroids,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26679053
DOI: 10.1016/j.canlet.2015.11.037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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