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Structure of bone morphogenetic protein 9 procomplex

6 Mar 2015

Abstract excerpt

Bone morphogenetic proteins (BMPs) belong to the TGF-β family, whose 33 members regulate multiple aspects of morphogenesis. TGF-β family members are secreted as procomplexes containing a small growth factor dimer associated with two larger prodomains. As isolated procomplexes, some members are latent, whereas most are active; what determines these differences is unknown. Here, studies on pro-BMP structures and...

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PMID: 25751889
DOI: 10.1073/pnas.1501303112

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