Previously transmitted HIV-1 strains are preferentially selected during subsequent sexual transmissions.

doi:10.1093/infdis/jis503

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Previously transmitted HIV-1 strains are preferentially selected during subsequent sexual transmissions.

The Journal of infectious diseases - 1 Nov 2012

Redd Andrew D, Collinson-Streng Aleisha N, Chatziandreou Nikolaos, Mullis Caroline E, Laeyendecker Oliver, Martens Craig, Ricklefs Stacy, Kiwanuka Noah, Nyein Phyu Hninn, Lutalo Tom, Grabowski Mary K, Kong Xiangrong, Manucci Jordyn, Sewankambo Nelson, Wawer Maria J, Gray Ronald H, Porcella Stephen F, Fauci Anthony S, Sagar Manish, Serwadda David, Quinn Thomas C

Abstract excerpt

BACKGROUND: A genetic bottleneck is known to exist for human immunodeficiency virus (HIV) at the point of sexual transmission. However, the nature of this bottleneck and its effect on viral diversity over time is unclear. METHODS: Interhost and intrahost HIV diversity was analyzed in a stable population in Rakai, Uganda, from 1994 to 2002. HIV-1 envelope sequences from both individuals in initially HIV-discordant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cluster Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV-1

Share to HIV Infections

Share to RNA, Viral

Share to Selection, Genetic

Share to Sequence Analysis, DNA

Share to Uganda

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 22997233
DOI: 10.1093/infdis/jis503
PMCID: PMC3466994

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Previously transmitted HIV-1 strains are preferentially selected during subsequent sexual transmissions.PMID 22997233Read ↗

Higher sequence diversity in the vaginal tract than in blood at early HIV-1 infection.Semantic proximity Read ↗

HIV-1 subtype distribution trends and evidence of transmission clusters among incident cases in a rural clinical cohort in southwest Uganda, 2004-2010.Semantic proximity Read ↗

HIV-1 Subtype Distribution and Diversity Over 18 Years in Rakai, Uganda.Semantic proximity Read ↗

Role of donor genital tract HIV-1 diversity in the transmission bottleneckSemantic proximity Read ↗

Molecular Epidemiology of HIV in an African Epidemic with Declining HIV incidence but High Prevalence: A Longitudinal, Population-based Study in UgandaSemantic proximity Read ↗

Human immunodeficiency virus type 1 env evolves toward ancestral states upon transmission to a new host.Semantic proximity Read ↗

Diversity in virus populations from genital secretions and peripheral blood from women recently infected with human immunodeficiency virus type 1.Semantic proximity Read ↗

HIV type 1 genetic variation in foreskin and blood from subjects in Rakai, Uganda.Semantic proximity Read ↗

Phylogenetic and Demographic Characterization of Directed HIV-1 Transmission Using Deep Sequences from High-Risk and General Population Cohorts/Groups in UgandaSemantic proximity Read ↗

Infection with multiple human immunodeficiency virus type 1 variants is associated with faster disease progression.Semantic proximity Read ↗

Bottlenecks in HIV-1 transmission: insights from the study of founder virusesSemantic proximity Read ↗

The intra-host evolutionary and population dynamics of human immunodeficiency virus type 1: a phylogenetic perspectiveSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.