Article
Monotypic human immunodeficiency virus type 1 genotypes across the uterine cervix and in blood suggest proliferation of cells with provirus.
Journal of virology - 1 Jun 2009
Bull Marta E, Learn Gerald H, McElhone Scott, Hitti Jane, Lockhart David, Holte Sarah, Dragavon Joan, Coombs Robert W, Mullins James I, Frenkel Lisa M
Abstract excerpt
Understanding the dynamics and spread of human immunodeficiency virus type 1 (HIV-1) within the body, including within the female genital tract with its central role in heterosexual and peripartum transmission, has important implications for treatment and vaccine development. To study HIV-1 populations within tissues, we compared viruses from across the cervix to those in peripheral blood mononuclear cells (PBMC)...
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