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Article

TLR8 ligation induces apoptosis of monocytic myeloid-derived suppressor cells

14 Dec 2017

Abstract excerpt

Myeloid-derived suppressor cells (MDSCs) accumulate in tumors and the peripheral blood of cancer patients and demonstrate cancer-promoting activity across multiple tumor types. A limited number of agents are known to impact MDSC activity. TLR8 is expressed in myeloid cells. We investigated expression of TLR8 on MDSC and the effect of a TLR8 agonist, motolimod, on MDSC survival and function. TLR8 was highly...

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PMID: 29345064
DOI: 10.1002/jlb.5ab0217-070r

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