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Article

PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features.

Oncotarget - 2 May 2017

Teye Emmanuel K, Sido Abigail, Xin Ping, Finnberg Niklas K, Gokare Prashanth, Kawasawa Yuka I, Salzberg Anna C, Shimko Sara, Bayerl Michael, Ehmann W Christopher, Claxton David F, Rybka Witold B, Drabick Joseph J, Wang Hong-Gang, Abraham Thomas, El-Deiry Wafik S, Brodsky Robert A, J Hohl Raymond, Pu Jeffrey J

Abstract excerpt

Previous studies have linked increased frequency of glycosylphosphatidylinositol-anchor protein (GPI-AP) deficiency with genomic instability and the risk of carcinogenesis. However, the underlying mechanism is still not clear. A randomForest analysis of the gene expression array data from 55 MDS patients (GSE4619) demonstrated a significant (p = 0.0007) correlation (Pearson r =-0.4068) between GPI-anchor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28187452
DOI: 10.18632/oncotarget.15136
PMCID: PMC5444711

Genes

PIGN
GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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